PhD in Biochemistry and Pathobiochemistry

The objective of studies in the study program of Biochemistry and pathobiochemistry is the preparation of the student for an autonomous scientific explanation of molecular principles of life processes in the human organism, their direction, and molecular mechanisms of their disorders.

Biochemistry and pathobiochemistry are concerned with the issues of biomacromolecules, i.e. proteins and enzymes, polysaccharides, lipoproteins, and nucleic acids, as well as their component units and other important low molecular weight substances in living systems (amino acids, peptides, saccharides, lipids, steroids). The objective of the field is also an explanation of their mutual changes and their role in cell signaling. Another very important sphere is the research into super-molecular cell structures and their function. The program also focuses on the principles of disorders of the said structures and their functions, i.e. on the molecular nature of the origin, development, and course of pathologic states. One important part of the study is the physiological and pathogenetic importance of reactive forms of oxygen and nitrogen; the subject of the study program is mechanisms of action of the substances that damage the nucleic acids and biomembranes. In the study program, attention is paid to research into disorders of cell signaling, including cancerogenesis and atherogenesis, molecular nature of hereditary and acquired metabolic disorders, mechanisms of maintenance of stable internal environment (metabolic and ionic balance), and the allied pathologic disturbances. The program also deals with the development of new laboratory diagnostic methods.

According to article 3, paragraph 1, second sentence of the Code of Admission Procedure of Charles University, this program of study is offered without specialization.