This course aims to provide students with knowledge and critical understanding of the molecular biology, cell biology and biochemistry of eukaryotic parasites and their vectors.
Topics will be taught through formal lectures to convey essential concepts and factual information, guided reading to explore topics in greater depth, interactive tutorials to develop critical understanding, student seminars to reinforce learning outcomes and gain practice in presentational skills, and practical sessions to gain technical competence and to illustrate important concepts in action.
The use of recombinant DNA technology, molecular cell biology and biochemical techniques as research tools in parasitology and vector biology.
Surface antigens of parasites and their role in invasion and survival in mammalian hosts.
The molecular and biochemical basis of antigenic variation and antigenic diversity in protozoan parasites.
Surface membrane enzymes and transporters and their role in acquisition of nutrients by parasites.
Invasion and survival of intracellular parasites.
Survival and development of parasites in their arthropod vectors and parasite/vector interaction.
Unique biochemical pathways found in parasites and their potential for exploitation as chemotherapeutic targets; empirical and rational drug design.
Molecular and developmental biology of insects and other vectors.
Molecular basis of insecticide resistance in vectors.
Molecular and developmental biology of helminth parasites; structure and function of the surface membrane/cuticle.
Unusual features of gene organisation and regulation in kinetoplastid parasites.
- Organelles and subcellular compartments in parasites.
This course is suitable for people who require an update and to gain technical competence on the essentials of molecular and cellular biology.
- Critically review the exploitation of biochemical differences between parasites and their hosts in relation to parasite chemotherapy and vaccine research
- Discuss the importance of differences in the molecular biology, cell biology and biochemistry of eukaryotic parasites from those of their vectors and mammalian hosts
- Apply a range of techniques in molecular cell biology and critically interpret the outcomes
- Identify the unique adaptations of parasites and critically review their importance in survival and completion of their life cycles
This school offers programs in:
Last updated November 27, 2015